Michael Rosenfeld

Dr. Michael Rosenfeld studies nutrition and cardiovascular disease, the role of nutrition in regulation of gene expression, lipid and lipoprotein metabolism, and the pathology of atherosclerosis. The current focus of the Rosenfeld Lab is on the accelerated vascular disease associated with obesity, type 2 diabetes, and chronic kidney disease. Specifically, the lab is studying the potential roles of the bone-related proteins osteoprotegerin, receptor activator of NFkB, and receptor activator of NFkB ligand in mediating the accelerated vascular calcification and atherosclerosis that occur in people with chronic kidney disease. The lab is also doing proteomic and genomic discovery studies with macrophages from uremic humans and mice to unveil new therapeutic pathways for chronic kidney disease. Dr. Rosenfeld also studies the roles of air pollution exposure and respiratory infection on atherosclerosis.